Design of Experiments (DOE) for Method Validation and Laboratory Studies

This course covers the design of experiments (DOE) and analysis of laboratory generated data. Laboratory applications of DOE include Measurement System Analysis (MSA), designed studies used in method validation and improvement, verification of competency, and evaluations of components of measurement uncertainty. The participant will learn the basic tools and potential pitfalls of experimental design and analysis of variance (ANOVA) by studying laboratory examples.


Intermediate Statistics for Laboratory Professionals (EMU 200) or equivalent knowledge.


The participant will need to bring a laptop computer (PC or MAC) with Microsoft Excel or similar spreadsheet installed. Please note that the tablet and smart phone versions of Excel and other spreadsheets do not have the full functionality of the PC versions and the participant may not be able to utilize all the power of the spreadsheet covered during the training.

Target Attendees

Target learners include Laboratory Managers, Engineers, Scientists, or Technicians.

Learning Outcomes

After successful competition of this course, the participant will be able to:

  1. Explain the difference between discrete and continuous variables, and dependent and independent variables;
  2. Develop a DOE plan to meet specific objectives;
  3. Describe and apply randomization and blocking;
  4. Set-up and interpret outcomes of Measurement System Analysis (MSA);
  5. Interpret outputs of DOE analysis; and
  6. Apply DOE to Method Validation, improvement and components of measurement uncertainty




LEUs Awarded

1.4 LEUs Awarded*



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